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Development of Iron-Based Nanoparticles for Hyperthermia
Introduction
• Developed iron-based nanoparticles (IONPs) for targeted hyperthermia treatment.
• Used a co-precipitation method to synthesize IONPs, achieving a particle size of ~11nm.
• Functionalized IONPs with hyaluronic acid (HA) to enhance biocompatibility and prevent aggregation.
• Characterized IONPs using SEM, TEM, VSM, and XRD techniques.
• Evaluated the heating effects of IONPs and HA-coated IONPs (HA-IONPs) using a radiofrequency (RF) generator.
• Created a tissue-mimicking phantom to test the RF-induced heating in a simulated biological environment.
Situation
• Cancer is a leading cause of death worldwide, and conventional treatments often have adverse side effects.
• Hyperthermia, a minimally invasive treatment using heat to destroy cancer cells, has shown promise.
• IONPs, with their biocompatibility and superparamagnetic properties, are ideal for targeted hyperthermia.
Task
• Synthesize and characterize IONPs suitable for hyperthermia applications.
• Evaluate the RF-induced heating effects of IONPs and HA-IONPs.
• Develop a tissue-mimicking phantom to simulate the biological environment for testing.
Action
• Synthesized IONPs using a co-precipitation method.
• Functionalized IONPs with HA to improve biocompatibility and prevent aggregation.
• Characterized IONPs using SEM, TEM, VSM, and XRD techniques to analyze morphology, size, magnetic properties, and crystallinity.
• Tested the RF-induced heating effects of IONPs and HA-IONPs using a 27 MHz RF generator.
• Created a tissue-mimicking phantom using agarose, sodium chloride, and sucrose to simulate normal and abnormal tissues.
Result
• Successfully synthesized IONPs with an average size of ~11nm.
• HA-IONPs exhibited enhanced biocompatibility and stability compared to bare IONPs.
• HA-IONPs generated a temperature increase of ~10°C under RF induction, suitable for hyperthermia applications.
• The tissue-mimicking phantom showed minimal temperature changes under RF induction, indicating the safety of the technique for surrounding healthy tissues.
Conclusion
• The project successfully demonstrated the feasibility of using IONPs for RF-induced hyperthermia.
• HA-IONPs hold potential for targeted and minimally invasive cancer treatment.
• Further research and development are needed to optimize the technique and evaluate its efficacy in pre-clinical and clinical settings.